Clinical Research Principal Investigator MD/DO

Principal Investigator (MD or DO) — Clinical Research

Location: Miami, Florida
Organization: Optimus U
Schedule: Full-time or part-time

Optimus U is seeking a licensed MD or DO to serve as an active Principal Investigator for Phase I–IV clinical trials. Our primary research areas include MASH/liver disease, obesity, diabetes, cardiometabolic conditions, and Alzheimer’s disease.

Responsibilities

• Provide direct medical and safety oversight.

• Confirm eligibility and supervise informed consent.

• Review laboratories, adverse events, SAEs, medications, and study data.

• Ensure protocol, GCP, FDA, and IRB compliance.

• Supervise and train delegated research staff.

• Work with sponsors, CROs, monitors, auditors, and regulatory authorities.

• Remain available on-site for participant care, urgent safety matters, and inspections.

Qualifications

• MD or DO degree.

• Active, unrestricted Florida medical license.

• Board-certified or board-eligible.

• Strong clinical judgment and documentation skills.

• Clinical research experience preferred; PI or Sub-Investigator experience is a plus.

• GCP knowledge and Spanish fluency are preferred.

This is a hands-on leadership position—not a name-only PI role. Competitive compensation based on experience, availability, and responsibilities.

To apply, send your CV to through our inquiry form.